S-Adenosyl Methionine or SAMe is made from the amino acid, methionine. It supports brain functions and keeps neurotransmitters healthy. It helps improve the mood, alleviates depression, and mental state. It also prevents osteoarthritis from progressing by improving the flexibility of the joints and prevents degeneration of the joints. It helps reduce mental and physical fatigue. It improves immune system function that protects the body from infections. It also helps maintain the cardiovascular health. It is a strong antioxidant that protects the cells and tissues from free radical damages. It also benefits the liver, particularly those suffering from alcoholism, by aiding in the removal of toxins the body.