Bioperine is an extract from the fruit of Piper nigrum L (black pepper) or Piper longum L (long pepper) that contains 95 percent of piperine. Black pepper is a common household spice. Extract from black pepper has also been used extensively as a medicine. To reach the greatest quality during the harvest, the pepper is reaped before ripening and after that is placed to dry under the sun rays. Bioperine is known for its effect to enhance the efficiency of many supplement nutrients. Bioperine acts to enhance the body’s natural therogenic activity – giving the name thermonutrient. This enhancement brings about increased metabolic rate creating demand for supple of many nutrients such as vitamins, minerals, herbals, amino acids. It sets in motion a process that brings about better digestion and faster gastrointestinal absorption.

Caffeine is a xanthine alkaloid that has a psychoactive stimulant effect. It may be found in many plant species but the main source of caffeine is coffee or cocoa bean. It is a potent stimulant that causes the heart rate to increase, muscles to tighten up, and the pupils to dilate. It activates the adrenaline that gives a boost of energy. It also reduces the symptoms of asthma. It helps open up the airways for ease of breathing. It increases the metabolism and breaks down fats. It also helps increase muscle strength. It also prevents chronic fatigue syndrome. Caffeine helps ease headache. It also reduces the risk of diabetes, Parkinson’s disease, and colon cancer.

Synephrine is an active compound that may be found in the fruit called Citrus aurantium or Zhi Shi in Chinese. Its chemical composition is similar to ephedrine and pseudo-ephedrine that may be found in most over the counter cold or allergy medications, weight loss and energy supplements. Unlike ephedrine, Synephrine is considered to be semi-selective sympathomimetic that targets tissues such as fats instead of the heart. It also helps the metabolism without the negative effects of ephedrine to the nervous system. It also increases the energy level, helps the body burn fat and promotes weight loss. It also aids the body to increase the quickness of caloric expenditure.

Synthetic Guggulsterones, which is a form of orally administered guggulipid, which increases T3 (tryiidothyronine) levels in animal models. T3 is the conversion product of T4, which is produced by the thyroid gland. Thyroid hormone levels are closely involved in metabolic function. Increased thyroid levels can cause more fat to be burned and stored. While on a diet, the body responds by decreasing T3 levels, therefor decreasing metabolic rate. It is not known how guggulipid increases T3 levels. Guggul, also called guggulipid, is an ethyl acetate extract of the gum resin of the guggul tree.

Yohimbe is an alkaloid and the active ingredient of a medicinal herb also known as Pausinystalia yohimbe, formerly named Corynanthe yohimbe. It is noted as a stimulant drug and also as an aphrodisiac. While the medicinal community has conducted numerous studies of yohimbe in conjunction with sexual dysfunctions, in veterinary medicine, yohimbine is employed as the antidode to anesthesia stemming from the drug xylazine in large and small animals. In recent times, yohimbine has been found to instigate fat loss in athletes when taken orally. There are also some formulations available, for a significant price, where yohimbine can be directly applied transdermally to adipose tissue, leading to a local reduction. This application is still in experimentation and should not be used without professional assistance.