6,7 Dihydroxybergamottin is a furanocoumarin. This ingredient is generally present in grapefruit. It is also present in bergamot oil from which it derives its name. To a lesser extent it is even available in other citrus fruits and essential oils. Consuming 6, 7 dihydroxybergamottin supplements have an affect on the metabolism of various pharmaceutical drugs. 6, 7 Dihydroxybergamottin inhibits isforms of cytochrome P450 enzyme, especially CYP3A4. It is because of this feature that the enzyme prevents oxidative metabolism of some drugs, which results in accumulation of the drug in the bloodstream. According to some clinical studies 6, 7 dihydroxybergamottin hamper the body’s ability to digest caffeine, thereby extending its presence in the body. Patients under medication must therefore avoid consuming grapefruit and related supplements.

Caffeine may be the most popular legal addictive stimulant that is available to mankind. Besides coffee, tea, guarana and kola nut have excess amount of this xanthine alkaloid, which is actually acting as a psychoactive drug. In several plants, caffeine is an effective insect repellant, but this trimethylxanthine is deemed by the Food and Drug Administration as generally safe food substance. It is an antagonist of adenosine receptors. The effect of caffeine is individual and may more or less increase the ability to perform physical and mental labor. It reduces the effects of fatigue and may in long term help predominantly men reduce the risk of developing Parkinson’s disease. It has also been observed that caffeine has nootropic effects, furthermore, regular consumption of caffeine may significantly reduce the risk of heart diseases.

Capsaicin is the chief capsaicinoid found in chilli peppers that belong to the group Capsicum. This phytochemical causes a burning sensation in any tissue that comes into contact. It is used in the preparation of varied topical ointments developed to alleviate the pain of peripheral neuropathy. The typical burning sensation is caused when capsaicin interact with the nerve cells. It is also believed that intake of capsaicin can cause a euphoric sensation due to the release of endorphins. As per studies, capsaicin can also alleviate symptoms associated with arthritis, improve flexibility of the joints, reduce psoriasis symptoms, and protect against gastric ulcers. And that's not all - research suggests that a combination of capsaicin and green tea can be effectively used in weight management too. This is because this combination promotes a feeling of fullness.

Yerba Matte or Ilex paraguariensis commonly grows in South America. It contains about twenty four vitamins and minerals, fifteen amino acids, eleven types of polyphenols, caffeine, and contains a high level of antioxidants. It is considered to be the most balanced stimulant and revered as the “drink of the gods”. It contains xanthine alkaloids such as theobromine, caffeine and theophylline, and saponins that stimulate the immune system, enhance the memory and focus, and suppress appetite. Yerba Mate also helps regulate the blood sugar and cholesterol level. It also helps burn the fat and fight free radical damages to cells that may cause cancer and aging. It also helps in cleansing the blood, and may act as a diuretic

Yohimbine HCL is a tryptamine alkaloid obtained from a medicinal herb Pausinystalia yohimbe, also known as yohimbe or yohimbe bark. This supplement belongs to the group of stimulant drugs, which has aphrodisiac qualities. Yohimbine chloride—a standardized form of yohimbine—is also used to treat erectile dysfunction. It can also be used to treat sexual side effects caused by some antidepressants (SRRIs), female hyposexual disorder and is also a blood pressure boosting agent and treats orgasmic dysfunction in men. Used orally as a supplement causes significant fat loss in athletes. Yohimbine is an alkaloid obtained from the bark of Pausinystalia yohimbe Pierre where the active ingredient yohimbine HCL (indole alkaloid) is obtained from.