Bioperine is an extract from the fruit of Piper nigrum L (black pepper) or Piper longum L (long pepper) that contains 95 percent of piperine. Black pepper is a common household spice. Extract from black pepper has also been used extensively as a medicine. To reach the greatest quality during the harvest, the pepper is reaped before ripening and after that is placed to dry under the sun rays. Bioperine is known for its effect to enhance the efficiency of many supplement nutrients. Bioperine acts to enhance the body’s natural therogenic activity – giving the name thermonutrient. This enhancement brings about increased metabolic rate creating demand for supple of many nutrients such as vitamins, minerals, herbals, amino acids. It sets in motion a process that brings about better digestion and faster gastrointestinal absorption.

Evodiamine has been used in Chinese medicine and by Chinese herbalists for centuries for weight loss purposes. It is an extract from a plant, Evodia or Tetradium, actually a tree genus of the family Rutaceae. The bee bee tree, as it is called besides Euodia and Evodia, provide a bioactive alkaloid that the Chinese have nicknamed Wu-Chu-Yu. This extract not only can interact with UCP1, a thermogenic protein, which as a consequence burns energy as heat, but also has shown in studies on mice to reduce the fat uptake. Evodiamine seems to increase the resting temperature of humans, whereby increased fat and calories are burned in order to supply the heat. Deemed a breakthrough in thermogenesis, evodiamine is subject of several clinical studies.

Green Tea Extract- By increasing the body's metabolism, it is widely believed that green tea extract largely aids in weight loss.

Guggulsterone is a plant sterol found in the resin of the guggul plant, Commiphora mukul. It acts as an antagonist of the farnesoid X receptor, which was earlier believed to result in decreased cholesterol synthesis in the liver.

Hoodia Gordonii is a water retaining plant, also known as a succulent, which grows without leafs. Being native to the south of Africa, it has been in use for an indeterminable amount of time as an appetite suppressant. It is very easily identifiable, because the flowers of this plant have a rotten meat odor. The ingredient of the plant which is responsible for the appetite suppressing effects has been named P57. It is a steroidal glycoside which seems to act directly to the central nervous system’s mechanisms and supposedly raises the content of adenosine triphosphate in brain by at least a half. The effects of P57 in trials were registered as capable to reduce food intake by some fifty per cent on a daily basis.

Kelp is algae belonging to the class Phaeophyceae. These are seaweeds and exist in a number of commercially important species. Since these are marine organisms, they obtain their nutrition from the sea and as a result, a number of important minerals get incorporated in their bodies. They are high in iodine which is the necessary component of thyroid hormones. These hormones maintain the metabolism of the body properly. Other minerals found in it are calcium, magnesium, phosphorus, potassium, iron and sodium. All these minerals are vital for the body for various functions. Kelps also contain the vitamins A, B1, B2, C and E and many amino acids. It finds wide applications from the food industry to the medicine industry.

L-Tyrosine is a non-essential amino acid, which is used by the cells in order to synthesize the proteins and appears to help stabilize ones mood during periods of high stress levels.

Niacin, also called Vitamin B3, is a water-soluble vitamin needed for the conversion of food into energy so that it may be used by the body. Niacin also helps metabolize protein, sugar and fat.

Oil of Clove.

Pantothenic Acid, commonly called vitamin B5, is water soluble and is needed by every cell in the body to maintain good health. It helps in breaking down carbohydrates, fats and proteins to provide the body with energy. It assists in the production of red blood cells and hormones and ensures a healthy pregnancy. It is also known to lower triglyceride and cholesterol levels in the body. It helps in reducing stress and treating people with rheumatoid arthritis. Pantothenic acid is found in small quantities in almost all foods but abundantly in meats, fish, poultry, avocados, peas, broccoli and whole grains. A deficiency which is rare, leads to leg cramps, gastrointestinal problems, anemia, insomnia, depression, a burning sensation in the limbs and a weakened immune system.

Pyridoxine Hydrochloride- Originally called vitamin B6, or the rat antidermatitis factor, pyridoxine is a vital component of many coenzymes involved in amino acid metabolic processes. Pyridoxine hydrochloride is pyridoxine molecule bound to hydrochloride ion to maintain its stability until acted upon by the digestive process. It is readily absorbed in the intestines and then enters the circulation as the active coenzyme, pyridoxal phosphate or pyridoxamine phosphate. Either of these forms are directly involved in the decarboxylation and transamination of amino acids. Pyridoxine also takes part in the biochemical reactions in the gray matter of the central nervous system. Furthermore, it catalyzes urea production, production of essential fatty acids and the conversion of tryptophan to niacin. That is why a deficiency in vitamin B6 would entail a deficiency in Vitamin B3 (niacin) called Pellagra. It has been observe din animal studies that prolonged deficiency in pyridoxine resulted to epileptiform episodes, which may be related to its functions in the brain and spinal cord gray matter. On the other hand, rats that were injected with high doses of Vitamin B6 (3 g/kg) experienced total organ shutdown leading to death. In humans, being a water-soluble vitamin, it is excreted through the urine and its storage is quite limited. Therefore, toxicity is very unlikely.

Rhodiola can help increase resistance against fatigue and can reduce stress. Classified as adaptogens among the herbs, it prevents different harmful impacts caused by physical and mental stress and illness. Rhodiola Rosea is particularly helpful for athletes because of its adaptogenic properties and its capability to enhance efficiency of mitochondrial respiration in skeletal muscle. It also improves mental work capacity and resists mental fatigue. Research has found that it helps protect against cancer. It can also be beneficial for people who suffer from high altitude sickness. Its intake can better endurance exercise capacity in young people and may also benefit people suffering from certain kinds of glucose level and cardiac conditions. Rhodiola Rosea helps prevent ischemic brain damage development.

Riboflavin, also called Vitamin B2, is naturally manufactured by the body. Riboflavin is needed for the proper use of oxygen and amino acids, carbohydrates and fatty acids. Riboflavin is also utilized by Vitamin B6 in the body and is used to manufacture niacin. Riboflavin is especially needed when eating large amounts of protein.

Thiamine is a water-soluble vitamin with no known toxic effects if taken with other members of the vitamin B complex. Thiamine is essential to a strong appetite and to enable the body to use sugars and other carbohydrates.

Vinpocetine is a compound that is derived from a substance found in the leaves naturally called vincamine. Vinpocetine was established in 1960s. This was available in Japan and Europe with prescription and in Canada and the United States it was available in health food stores as well as online as dietary supplement. Vinpocetine increases the blood circulation and reduces the impairment in the brain. Vinpocetine is given to people suffering with Alzheimer’s disease as a complementary treatment. It enhances the use of oxygen in the brain and protects the brain cell from damage. Thereby it works in enhancing the blood flow towards the brain. Vinpocetine prevents strokes and memory disturbances. Vinpocetine is useful in improving, hearing, eyesight and also in alleviating problems that are connected to menopause. Vinpocetine has effect on the damaged areas in the brain and is also an anti-oxidant. So it shields the brain from aging. The dosage recommended is 5mg tablet twice or thrice daily.

Vitamin B12 is required for the normal functioning and development of the nervous system, blood cells and brain. It’s a water soluble vitamin which is used to elevate mood, improve energy levels and concentration, to boost immune system and in sleeping disorders. Severe deficiency of Vitamin B12 can lead to pernicious anemia. It is also used for lowering high homocysteine levels which may contribute to heart disease, asthma, AIDS, to prevent cervical and other cancers, memory loss, osteoporosis, allergies and skin infections. It also helps to prevent atherosclerosis, multiple sclerosis, and kidney and gum disease. Vitamin B12 is added in almost all multi-vitamin B complex supplements. Deficiency of Vitamin B12 in infants can lead to megaloblastic anemia, delayed developments and movement disorders. Studies have proved that when used in combination with folic acid, it can prevent heart diseases.